Medicine patent pool–pharma philanthropy or PR?

Medicine patent pool--pharma philanthropy or PR?

Merck lately signed an settlement with The Medicines Patent Pool (MPP) to license mental property regarding pediatric formulations of its integrase HIV drug, raltegravir (Ral) (the ‘Settlement’). The Settlement is alleged to clear the best way for cheaper formulations to be used in growing and a few center revenue international locations and permits for the event of novel pediatric formulations of Ral in addition to novel combos. Merck’s license is royalty free and beneath the phrases of the Settlement, producers anyplace on the earth who meet the standard assurance standards, can manufacture and promote pediatric variations of the drug within the licensed international locations beneath the agreed situations with out paying a royalty to Merck.

The Settlement covers at the very least 92 international locations and MPP reviews that 98.1% of youngsters with HIV within the growing world reside within the included international locations. The Settlement has been criticized as a public relations train. The article asks if the criticism is justified and explores a number of facets of the Settlement in addressing the query.

Drug promotion tactics-yet one other pharma deception?

There isn’t a doubting that in latest instances, the pharmaceutical trade has been met with rising scepticism and outright distrust from many quarters. That is primarily in relation to the controversy surrounding many drug corporations’ determination to withhold adverse scientific trial information from public scrutiny. The follow of non-disclosure regarding such adverse findings results in erroneously exaggerated claims of efficacy or minimised reviews of hurt in relation to a drug.

Within the UK, the All Trials Initiative is spearheading the lobbying of presidency, regulators and analysis our bodies to impose obligatory disclosure of all scientific trial information. However what if these initiatives truly succeeded in reaching their targets? Would this actually signify an absolute victory over the pharmaceutical trade’s use of misleading techniques to mislead medical doctors and sufferers alike? Or have they got different methods and technique of manipulation?

Crowdsourcing in pharma: a strategic framework.

Conceptually, all organizations might be described as coordinated actors working collectively to ship a product(s), or present a service(s). For organizations to stay aggressive, you will need to have processes that look outward for exterior ‘improvements’ that would enhance how work is completed, and what’s delivered. We current a complete assessment of a wide range of processes that pharmaceutical corporations have used to interact exterior actors (‘the gang’) to offer innovation within the service of delivering novel therapeutic brokers. This culminates in a framework that gives a consolidated view of crowdsourcing processes, which in flip allows a strategic software of a crowdsourcing methodology primarily based on drawback kind.

Medicine patent pool--pharma philanthropy or PR?

Phytol in a pharma-medico-stance.

This examine goals to assessment phytol (PYT), by means of printed articles, periodicals, magazines and patents, which have been retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and INPI databases. Among the many 149 articles and 62 patents, 27.52% articles and 87.09% sufferers have been discovered on the searched matter, PYT and its sources and synthesis and metabolism; then adopted by 15.44% and 14.77% articles on PYT in cytotoxicity/most cancers/mutagenicity/teratogenicity and PYT in neurological ailments, respectively.

Within the pharma-medico viewpoint, PYT and its derivatives have been evident to have antimicrobial, cytotoxic, antitumorous, antimutagenic, anti-teratogenic, antibiotic-chemotherapeutic, antidiabetic, lipid decreasing, antispasmodic, anticonvulsant, antinociceptive, antioxidant, anti-inflammatory, anxiolytic, antidepressant, immunoadjuvancy, hair development facilitator, hair fall protection and antidandruff actions.

In any other case, the necessary biometebolite of PYT is phytanic acid (PA). Proof reveals PA to have cytotoxic, anticancer, antidiabetic, lipid decreasing and aniteratogenic actions. As well as, it might be thought-about as an necessary biomarker for some ailments similar to Refsum’s Illness (RD), Sjögren Larsson syndrome (SLS), rhizomelic chondrodysplasia punctata (RZCP), power polyneuropathy (CP), Zellweger’s illness hyperpipecolic academia (ZDHA) and associated ailments. Thus, phytol could also be thought-about as a brand new drug candidate.

Better of each worlds: combining pharma information and cutting-edge modeling expertise to enhance in Silico pKa prediction.

In a singular collaboration between a software program firm and a pharmaceutical firm, we have been in a position to develop a brand new in silico pKa prediction software with excellent prediction high quality. An present pKa prediction technique from Simulations Plus primarily based on synthetic neural community ensembles (ANNE), microstates evaluation, and literature information was retrained with a big homogeneous information set of drug-like molecules from Bayer.

The brand new mannequin was thus constructed with curated units of ∼14,000 literature pKa values (∼11,000 compounds, representing literature chemical area) and ∼19,500 pKa values experimentally decided at Bayer Pharma (∼16,000 compounds, representing trade chemical area). Mannequin validation was carried out with a number of take a look at units consisting of a complete of ∼31,000 new pKa values measured at Bayer. For the biggest and most tough take a look at set with >16,000 pKa values that weren’t used for coaching, the unique mannequin achieved a imply absolute error (MAE) of 0.72, root-mean-square error (RMSE) of 0.94, and squared correlation coefficient (R(2)) of 0.87. The brand new mannequin achieves considerably improved prediction statistics, with MAE = 0.50, RMSE = 0.67, and R(2) = 0.93. It’s commercially obtainable as a part of the Simulations Plus ADMET Predictor launch 7.0.

Primary Rat (Wistar Han) Hepatocytes, Suspension

T0105 5x10^5 cells / 1.0 ml
EUR 1375

Primary Minipig (Gottingen) Hepatocytes, Suspension

T0113 5x10^5 cells / 1.0 ml
EUR 1375

Primary Monkey (Cynomolgus) Hepatocytes, Suspension

T0111 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rat (Sprague Dawley) Hepatocytes, Suspension

T0103 5x10^5 cells / 1.0 ml
EUR 1375

Primary Rabbit (New Zealand White) Hepatocytes, Suspension

T0115 5x10^5 cells / 1.0 ml
EUR 1375

Primary Human Hepatocytes, Metabolism Qualified, Suspension

T0123 5x10^5 cells / 1.0 ml
EUR 1375

MA104 FROZEN SUSPENSION 100 ME

65-00100DH each Ask for price

Bovine Catalase Suspension

IBOCATLSP100ML each
EUR 653
Description: Bovine Catalase Suspension

Bovine Catalase Suspension

IBOCATLSP10ML each
EUR 99
Description: Bovine Catalase Suspension

Suspension Flasks, 25ml, Vent

25-212 10 per Sleeve, 200 Flasks/Unit
EUR 103.38
Description: Surface Area: 12.5cm2

Suspension Flasks, 50ml, Vent

25-213 10 per Sleeve, 200 Flasks/Unit
EUR 113.38
Description: Surface Area: 25.0cm2

Suspension Flasks, 250ml, Vent

25-214 5 per Sleeve, 100 Flasks/Unit
EUR 138.07
Description: Surface Area: 75.0cm2

Suspension Flasks, 600ml, Vent

25-215 5 per Sleeve, 40 Flasks/Unit
EUR 109.97
Description: Surface Area: 182.0cm2

Sarstedt 96 well suspension (83.3926.500) - PK50

4653305 PK50
EUR 129.25

Calcium Hydroxide 2M Suspension - 500ML

CAOH2M105 500ML
EUR 16.2

HS27 FROZEN SUSPENSION 50 MER

87-00050 each Ask for price
Description: Single or Mixed ; FreshFrozen

HELA-229 FROZEN SUSPENSION 50

75-00050DH each Ask for price
Description: Single or Mixed

500mL MEM for Suspension Culture

15-015-CV PK6
EUR 254.22

Human Fresh Hepatocytes, Suspension

ABC-TC3432 1 vial Ask for price
Description: Freshly isolated human hepatocytes represent a living biological system in which to measure metabolism, induction, toxicity, and transporter studies.

Rat Hepatocytes Suspension-Adult

ABC-TC4137 1 vial Ask for price
Description: Rat Hepatocytes Suspension - Adult

Freund's Complete Adjuvant (Suspension)

VAdv-Ly0004 10 mL
EUR 1663.2
Description: Freund's Adjuvant, Complete, Water-in-oil emulsion Vaccine adjuvant.

Calcium Hydroxide 2M Suspension - 1L

CAOH2M1 1L
EUR 21.6

Lid for suspension GB-A5051 - EACH

CEN5028 EACH
EUR 153.9

Suspension Culture Flask 25cm - PK200

169900 PK200
EUR 361.8

PRIMARY ANTIBODY DILUENT Reagent

GWB-Q00296 50 ml Ask for price

Suspension for use in rotors 4446/5694/4296 - EACH

CEN5026 EACH
EUR 263.25

Nunc 75cm2 Suspension Flask Filter Cap - PK100

156800 PK100
EUR 332.1

C57BL/6 Mouse Hepatocytes Suspension-Adult

ABC-TC3192 1 vial Ask for price
Description: C57BL/6 Mouse Hepatocytes Suspension - Adult

Alkaline phosphatase Ammonium sulfate suspension

AZ140B 1MG
EUR 120.55

Alkaline phosphatase Ammonium sulfate suspension

AZ235B 1MG
EUR 139.34

Toxoplasma gondii whole cell antigen suspension

18-2003-3 3 ml
EUR 450

Greiner suspension culture multiwell plates - PK60

M3562-60EA PK60
EUR 267.3

Bordetella pertussis, Inactive Bacterial Suspension

15330-91 1ML
EUR 39.9

AlbuSorb™ LS (suspension) Kit (processes 25 preps)

ALS385-25 2.5 ml AlbuSorb suspension (includes 25 spin-filter assemblies and buffer)
EUR 460

Sodium Acetylide Suspension (18 wt. % slurry in xylene)

S960228 100g
EUR 144
Description: 1066-26-8

Rat Peritoneal Macrophages (fresh cells in suspension)

ABC-TC4192 1 vial Ask for price
Description: Rat peritoneal macrophages (RPMAC) are derived from the peritoneal cavity of Sprague–Dawley rats. RPMAC are negative for bacteria, yeast, fungi, and mycoplasma.

Lid with Bio-containment for Suspension A1560 - EACH

A1561 EACH
EUR 153.9

Encephalitozoon cuniculi whole cell antigen suspension

18-2002 1 ml
EUR 438

Rat Bone Marrow Neutrophils (fresh cells in suspension)

ABC-TC4089 1 vial Ask for price
Description: Rat bone marrow neutrophils (RBMNEUCs) are derived from the tibias and femurs of adult Sprague–Dawley rats. RBMNEUCs are immediately cryo-preserved or fresh cells in suspensionafter isolation.

Nunc Suspension Tissue Culture Dish 35mm Vented - PK500

171099 PK500
EUR 878.85

Glucose-6-Phosphate Dehydrogenase Suspension In 3

G02100 1000UN
EUR 320.28

Suspension light-metal with clamp lock flat top - EACH

CEN5044 EACH
EUR 513

Swingout rotor 4place without suspension angle 90 - EACH

CEN5056 EACH
EUR 1300.05

Lid with bio-containment for suspension GB-A4780 - EACH

CEN5046 EACH
EUR 143.1

Primary Opalescence Solution - 100ML

EPPOS01 100ML
EUR 136.35

CP Reagent Coloration Primary Solution Red - 100ML

CPPR01 100ML
EUR 232.2

Suspension Bucket Light Metal with Single-hand Clamp Lock - EACH

A1560 EACH
EUR 429.3

CP Reagent Coloration Primary Solution Blue - 100ML

CPPB01 100ML
EUR 156.6

Recombinant Protein A+G-Agarose suspension for Ig's purification

PRAG15-AS-1 1 ml
EUR 242.4

Recombinant Protein A+G-Agarose suspension for Ig's purification

PRAG15-AS-5 5 ml
EUR 781.2

CP Reagent Coloration Primary Solution Yellow - 100ML

CPPY01 100ML
EUR 156.6

MinuteTM Cell Suspension Isolation from Fresh/Frozen Tissues (50 tests)

CS-031 each
EUR 299

Recombinant Protein A-Agarose, affinity matrix suspension for IP (100 rxn)

PRTA16-AS-2 2 ml
EUR 132

Recombinant Protein A-Agarose, affinity matrix suspension for IP (250 rxn)

PRTA16-AS-5 5 ml
EUR 219.6

Recombinant Protein G-Agarose, affinity matrix suspension for IP (100 rxn)

PRTG16-AS-2 2 ml
EUR 139.2

Recombinant Protein G-Agarose, affinity matrix suspension for IP (250 rxn)

PRTG16-AS-5 5 ml
EUR 255.6

Recombinant Protein A+G-Agarose, affinity matrix suspension for IP (100 rxn)

PRAG25-AS-2 2 ml
EUR 139.2

Recombinant Protein A+G-Agarose, affinity matrix suspension for IP (250 rxn)

PRAG25-AS-5 5 ml
EUR 242.4

Ethyl 2-Chloro-2-formylacetateTechnical Grade, 5% Suspension in Benzene

E901885 500mg
EUR 1087
Description: 33142-21-1

Ethyl 2-Chloro-2-formylacetateTechnical Grade, 5% Suspension in Cyclohexane

E901889 5g
EUR 800
Description: 33142-21-1

Recombinant purified Protein-L Agarose, affinity matrix suspension for IP (100 rxn)

PRTL36-AS-2 2 ml
EUR 343.2

European Cuscuta TaqProbe qPCR. 100 RXN

TBS42009-100 100 RXN
EUR 1100

European Cuscuta TaqProbe qPCR. 50 RXN

TBS42009-50 50 RXN
EUR 600

Automatic Decapper, European/German Standard Plug

107001 1 pcs/cs
EUR 5018.31
Description: Automatic Decapper, European/German Standard Plug

L.R. White Embedding Media (for European Orders only)

17411H-500 500ml
EUR 204
Description: 7732-18-5

L.R. White Embedding Media (for European Orders only)

17411HUNC-500 500ml
EUR 286
Description: 7732-18-5

L.R. White Embedding Media (for European Orders only)

17411M-500 500ml
EUR 204
Description: 7732-18-5

L.R. White Embedding Media (for European Orders only)

17411MUNC-500 500ml
EUR 286
Description: 7732-18-5

L.R. White Embedding Media (for European Orders only)

17411S-500 500ml
EUR 204
Description: 7732-18-5

L.R. White Embedding Media (for European Orders only)

17411SUNC-500 500ml
EUR 286
Description: 7732-18-5

Immortalized European Sea Bass Brain Cells (DLB-1)

T0730 1x10^6 cells / 1.0 ml
EUR 3950

OPCA04490-100UG - THI2.1 Recombinant Protein (European mistletoe)

OPCA04490-100UG 100ug
EUR 668

OPCA04490-20UG - THI2.1 Recombinant Protein (European mistletoe)

OPCA04490-20UG 20ug
EUR 449

MyFuge™12 Mini Centrifuge 100-240V (European 2 prong plug)

C1012-E 1 PC
EUR 457.47

Incu-Mixer MP2™ Heated Plate Vortexer 115-240V European plug)

H6002-E 1 PC
EUR 2032.55

Fungi-Fluor® Kit for Fungal Detection (for European Orders only)

17442-E 1kit
EUR 285

Fungi-Fluor® Kit for Fungal Detection (for European Orders only)

17442E-1 1kit
EUR 285

European Pesticide Mix 2017-170 100 ug/mL (100 ppm) 1mLin Acetonitrile. - 1ML

EU-2017-170 1ML
EUR 87.75

OPCA04190-1MG - Tropomyosin Recombinant Protein (European house dust mite)

OPCA04190-1MG 1mg
EUR 1977

OPCA04190-20UG - Tropomyosin Recombinant Protein (European house dust mite)

OPCA04190-20UG 20ug
EUR 400

Vornado™ miniature vortexer, grey cup head, 100 to 240V with European Plug

BV101-E 1 PC
EUR 229.09

OPCA04190-100UG - Tropomyosin Recombinant Protein (European house dust mite)

OPCA04190-100UG 100ug
EUR 586

Orbi-Shaker™Jr with rubber mat platform (9.5"x8"), 100-240V (European 2 prong plug)

BT302-E 1 PC
EUR 1205.74

TBEV (European subtype, strain Neudoerfl) Envelope protein E, His Tag (HPLC verified)

ENE-T52H4 500ug
EUR 481.5
Description: TBEV (European subtype, strain Neudoerfl) Envelope protein E, His Tag (ENE-T52H4) is expressed from human 293 cells (HEK293). It contains AA Thr 118 - Lys 675 (Accession # P14336).

BenchWaver™ 3D Rocker with flat mat, 13.5x13" platform, 100-240V (European 2 prong plug)

B3D5000-E 1 PC
EUR 1548.97

OPCA04322-100UG - Major pollen allergen Aln g 1 Recombinant Protein (European alder)

OPCA04322-100UG 100ug
EUR 668

OPCA04322-20UG - Major pollen allergen Aln g 1 Recombinant Protein (European alder)

OPCA04322-20UG 20ug
EUR 449

OPCA04322-500UG - Major pollen allergen Aln g 1 Recombinant Protein (European alder)

OPCA04322-500UG 500ug
EUR 1534

Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial

CSB-EP318509TEM 11863 mg Ask for price

Orbi-Shaker™ MP with 4 position micro plate platform, 100-240V (European 2 prong plug)

BT1502-E 1 PC
EUR 1168.82

Vornado™ miniature vortex mixer with red cup head, 100 to 240V with European Plug Adapter

BV101-R-E 1 PC
EUR 229.09

Vornado™ miniature vortex mixer with blue cup head, 100 to 240V with European Plug Adapter

BV101-B-E 1 PC
EUR 229.09

Vornado™ miniature vortex mixer with green cup head, 100 to 240V with European Plug Adapter

BV101-G-E 1 PC
EUR 229.09

Vornado™ miniature vortex mixer with purple cup head, 100 to 240V with European Plug Adapter

BV101-P-E 1 PC
EUR 229.09

MyFuge™12 Plus Digital Mini Centrifuge with combination rotor 100-240V (European 2 prong plug)

C2212-E each
EUR 649
Description: - COMBI-Rotor for tubes and strips- Digital control up to 7,000 rpm / 2,739 xg!- Twice the capacity of traditional mini centrifuges- Near silent operation- Timer up to 99 mins.The unique rotor design of the new MyFuge 12 Plus eliminates the need to switch rotors (or use a separate centrifuge) when changing between microtubes and PCR strips. The included, COMBI-Rotor allows for simultaneous centrifugation of up to 12 microtubes and/or 4 PCR strips.In addition, the MyFuge 12 Plus features a large digital display with adjustable speed (up to 7,000 rpm) and a digital timer. With built in rcf conversion, speed can be set/displayed in rpm or rcf.The MyFuge 12 Plus combines power with intuitive functionality making it the perfect companion in any laboratory.

OPCA04311-1MG - Major pollen allergen Car b 1 isoform 2 Recombinant Protein (European hornbeam)

OPCA04311-1MG 1mg
EUR 2368

StripSpin™12D Digital Mini Centrifuge, holds 12 position PCR strips, 100-240V (European 2 prong plug)

C2248-E each
EUR 595
Description: - Unique rotor accepts 12-position PCR strips- Digital control up to 5,500 rpm- “Mini” sized, less than 8 inches wide- Timer up to 99 mins.The new StripSpin 12D digital mini centrifuge from Benchmark is uniquely designed for centrifugation of 12 position PCR strips. It features digital speed control up to 5,500 rpm, timer control up to 99 min., and a safety interlock to stop the centrifuge if the lid is opened during operation.With built in rcf conversion, speed can be set/displayed in rpm or rcf, the StripSpin 12D is the perfect solution for centrifugation of up to 4 x 12-position high efficiency PCR strips (or 48 x 0.2ml tubes) and includes a 2 year warranty.

OPCA04311-100UG - Major pollen allergen Car b 1 isoform 2 Recombinant Protein (European hornbeam)

OPCA04311-100UG 100ug
EUR 668

OPCA04311-20UG - Major pollen allergen Car b 1 isoform 2 Recombinant Protein (European hornbeam)

OPCA04311-20UG 20ug
EUR 449

ViPrimePLUS Porcine Reproductive and Respiratory Syndrome Virus - European Genotype RT-qPCR Kit, 1

QV5004 each Ask for price

MyFuge™ 5D Digital MicroCentrifuge with combination rotor, 4 x 5ml & 4 x 1.5/2.0ml, 100-240V (European 2 prong plug)

C2205-E each
EUR 595
Description: Includes rotor for all common centrifuge tubes up to 5ml'- Digital control up to 5,500 rpm / 1,690 xg- Conserves valuable bench space- Includes adapters for common blood tubes (12 x 75 mm)- Timer up to 99 mins.The myFuge™ 5D digital mini centrifuge includes a four position rotor that accepts a variety of 5ml tubes (including 5ml snap-cap and screw-cap centrifuge tubes, as well as 5ml blood collection tubes). In addition, the rotor has four positions for positions for standard microtubes (1.5/2.0ml) and offers optional adapters for 2ml cryotubes, 0.2ml PCR tubes, and 0.5ml microtubes, making it one of the most versatile and compact centrifuges in its class.The myFuge 5D offers digital speed control (up to 5,500 rpm). Timer is also controlled (up to 99 min.) with a safety interlock to stop the centrifuge if the lid is opened during operation. With built in rcf conversion, speed can be set/displayed in rpm or rcf. The myFuge 5D also comes with a 2-year warranty.

Sterile Pharmacol

PW1148F-1X100NO 1 unit
EUR 23.02
Description: Sterile Pharmacol

Prime Juice DNA Staining Reagent

LD011-1000 1 ml
EUR 10

EP Reagent Biuret Reagent - 100ML

1011601 1L
EUR 59.4

PEROXIDE BLOCKING REAGENT Reagent

GWB-Q00308 50 ml Ask for price

TruStrip WBV Tubulin protein quantitation & Western Blot Validation Kit (contains actin strips, primary antibodies and Western reagents 100 strips or 10 miniblot)

WBTUB100-K 1 Kit
EUR 634.8

Good predictions are solely of worth when delivered successfully to those that can use them. The brand new pKa prediction mannequin has been built-in into Pipeline Pilot and the PharmacophorInformatics (PIx) platform utilized by scientists at Bayer Pharma. Completely different output codecs permit custom-made software by medicinal chemists, bodily chemists, and computational chemists.

 

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