Merck lately signed an settlement with The Medicines Patent Pool (MPP) to license mental property regarding pediatric formulations of its integrase HIV drug, raltegravir (Ral) (the ‘Settlement’). The Settlement is alleged to clear the best way for cheaper formulations to be used in growing and a few center revenue international locations and permits for the event of novel pediatric formulations of Ral in addition to novel combos. Merck’s license is royalty free and beneath the phrases of the Settlement, producers anyplace on the earth who meet the standard assurance standards, can manufacture and promote pediatric variations of the drug within the licensed international locations beneath the agreed situations with out paying a royalty to Merck.
The Settlement covers at the very least 92 international locations and MPP reviews that 98.1% of youngsters with HIV within the growing world reside within the included international locations. The Settlement has been criticized as a public relations train. The article asks if the criticism is justified and explores a number of facets of the Settlement in addressing the query.
Drug promotion tactics-yet one other pharma deception?
There isn’t a doubting that in latest instances, the pharmaceutical trade has been met with rising scepticism and outright distrust from many quarters. That is primarily in relation to the controversy surrounding many drug corporations’ determination to withhold adverse scientific trial information from public scrutiny. The follow of non-disclosure regarding such adverse findings results in erroneously exaggerated claims of efficacy or minimised reviews of hurt in relation to a drug.
Within the UK, the All Trials Initiative is spearheading the lobbying of presidency, regulators and analysis our bodies to impose obligatory disclosure of all scientific trial information. However what if these initiatives truly succeeded in reaching their targets? Would this actually signify an absolute victory over the pharmaceutical trade’s use of misleading techniques to mislead medical doctors and sufferers alike? Or have they got different methods and technique of manipulation?
Crowdsourcing in pharma: a strategic framework.
Conceptually, all organizations might be described as coordinated actors working collectively to ship a product(s), or present a service(s). For organizations to stay aggressive, you will need to have processes that look outward for exterior ‘improvements’ that would enhance how work is completed, and what’s delivered. We current a complete assessment of a wide range of processes that pharmaceutical corporations have used to interact exterior actors (‘the gang’) to offer innovation within the service of delivering novel therapeutic brokers. This culminates in a framework that gives a consolidated view of crowdsourcing processes, which in flip allows a strategic software of a crowdsourcing methodology primarily based on drawback kind.
Phytol in a pharma-medico-stance.
This examine goals to assessment phytol (PYT), by means of printed articles, periodicals, magazines and patents, which have been retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and INPI databases. Among the many 149 articles and 62 patents, 27.52% articles and 87.09% sufferers have been discovered on the searched matter, PYT and its sources and synthesis and metabolism; then adopted by 15.44% and 14.77% articles on PYT in cytotoxicity/most cancers/mutagenicity/teratogenicity and PYT in neurological ailments, respectively.
Within the pharma-medico viewpoint, PYT and its derivatives have been evident to have antimicrobial, cytotoxic, antitumorous, antimutagenic, anti-teratogenic, antibiotic-chemotherapeutic, antidiabetic, lipid decreasing, antispasmodic, anticonvulsant, antinociceptive, antioxidant, anti-inflammatory, anxiolytic, antidepressant, immunoadjuvancy, hair development facilitator, hair fall protection and antidandruff actions.
In any other case, the necessary biometebolite of PYT is phytanic acid (PA). Proof reveals PA to have cytotoxic, anticancer, antidiabetic, lipid decreasing and aniteratogenic actions. As well as, it might be thought-about as an necessary biomarker for some ailments similar to Refsum’s Illness (RD), Sjögren Larsson syndrome (SLS), rhizomelic chondrodysplasia punctata (RZCP), power polyneuropathy (CP), Zellweger’s illness hyperpipecolic academia (ZDHA) and associated ailments. Thus, phytol could also be thought-about as a brand new drug candidate.
Better of each worlds: combining pharma information and cutting-edge modeling expertise to enhance in Silico pKa prediction.
In a singular collaboration between a software program firm and a pharmaceutical firm, we have been in a position to develop a brand new in silico pKa prediction software with excellent prediction high quality. An present pKa prediction technique from Simulations Plus primarily based on synthetic neural community ensembles (ANNE), microstates evaluation, and literature information was retrained with a big homogeneous information set of drug-like molecules from Bayer.
The brand new mannequin was thus constructed with curated units of ∼14,000 literature pKa values (∼11,000 compounds, representing literature chemical area) and ∼19,500 pKa values experimentally decided at Bayer Pharma (∼16,000 compounds, representing trade chemical area). Mannequin validation was carried out with a number of take a look at units consisting of a complete of ∼31,000 new pKa values measured at Bayer. For the biggest and most tough take a look at set with >16,000 pKa values that weren’t used for coaching, the unique mannequin achieved a imply absolute error (MAE) of 0.72, root-mean-square error (RMSE) of 0.94, and squared correlation coefficient (R(2)) of 0.87. The brand new mannequin achieves considerably improved prediction statistics, with MAE = 0.50, RMSE = 0.67, and R(2) = 0.93. It’s commercially obtainable as a part of the Simulations Plus ADMET Predictor launch 7.0.
Primary Rat (Wistar Han) Hepatocytes, Suspension |
T0105 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
Primary Minipig (Gottingen) Hepatocytes, Suspension |
T0113 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
Primary Monkey (Cynomolgus) Hepatocytes, Suspension |
T0111 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
Primary Rat (Sprague Dawley) Hepatocytes, Suspension |
T0103 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
Primary Rabbit (New Zealand White) Hepatocytes, Suspension |
T0115 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
Primary Human Hepatocytes, Metabolism Qualified, Suspension |
T0123 |
ABM |
5x10^5 cells / 1.0 ml |
EUR 1375 |
MA104 FROZEN SUSPENSION 100 ME |
65-00100DH |
Quidel |
each |
Ask for price |
Bovine Catalase Suspension |
IBOCATLSP100ML |
Innovative research |
each |
EUR 653 |
|
Description: Bovine Catalase Suspension |
Bovine Catalase Suspension |
IBOCATLSP10ML |
Innovative research |
each |
EUR 99 |
|
Description: Bovine Catalase Suspension |
Suspension Flasks, 25ml, Vent |
25-212 |
Genesee Scientific |
10 per Sleeve, 200 Flasks/Unit |
EUR 103.38 |
Description: Surface Area: 12.5cm2 |
Suspension Flasks, 50ml, Vent |
25-213 |
Genesee Scientific |
10 per Sleeve, 200 Flasks/Unit |
EUR 113.38 |
Description: Surface Area: 25.0cm2 |
Suspension Flasks, 250ml, Vent |
25-214 |
Genesee Scientific |
5 per Sleeve, 100 Flasks/Unit |
EUR 138.07 |
Description: Surface Area: 75.0cm2 |
Suspension Flasks, 600ml, Vent |
25-215 |
Genesee Scientific |
5 per Sleeve, 40 Flasks/Unit |
EUR 109.97 |
Description: Surface Area: 182.0cm2 |
HS27 FROZEN SUSPENSION 50 MER |
87-00050 |
Quidel |
each |
Ask for price |
|
Description: Single or Mixed ; FreshFrozen |
HELA-229 FROZEN SUSPENSION 50 |
75-00050DH |
Quidel |
each |
Ask for price |
|
Description: Single or Mixed |
Human Fresh Hepatocytes, Suspension |
ABC-TC3432 |
AcceGen |
1 vial |
Ask for price |
|
Description: Freshly isolated human hepatocytes represent a living biological system in which to measure metabolism, induction, toxicity, and transporter studies. |
Rat Hepatocytes Suspension-Adult |
ABC-TC4137 |
AcceGen |
1 vial |
Ask for price |
|
Description: Rat Hepatocytes Suspension - Adult |
Freund's Complete Adjuvant (Suspension) |
VAdv-Ly0004 |
Creative Biolabs |
10 mL |
EUR 1663.2 |
Description: Freund's Adjuvant, Complete, Water-in-oil emulsion Vaccine adjuvant. |
PRIMARY ANTIBODY DILUENT Reagent |
GWB-Q00296 |
GenWay Biotech |
50 ml |
Ask for price |
C57BL/6 Mouse Hepatocytes Suspension-Adult |
ABC-TC3192 |
AcceGen |
1 vial |
Ask for price |
|
Description: C57BL/6 Mouse Hepatocytes Suspension - Adult |
Alkaline phosphatase Ammonium sulfate suspension |
AZ140B |
Bio Basic |
1MG |
EUR 120.55 |
|
Alkaline phosphatase Ammonium sulfate suspension |
AZ235B |
Bio Basic |
1MG |
EUR 139.34 |
|
Toxoplasma gondii whole cell antigen suspension |
18-2003-3 |
Medicago |
3 ml |
EUR 450 |
Bordetella pertussis, Inactive Bacterial Suspension |
15330-91 |
NACALAI TESQUE |
1ML |
EUR 39.9 |
AlbuSorb™ LS (suspension) Kit (processes 25 preps) |
ALS385-25 |
Biotech Support Group |
2.5 ml AlbuSorb suspension (includes 25 spin-filter assemblies and buffer) |
EUR 460 |
Rat Peritoneal Macrophages (fresh cells in suspension) |
ABC-TC4192 |
AcceGen |
1 vial |
Ask for price |
|
Description: Rat peritoneal macrophages (RPMAC) are derived from the peritoneal cavity of Sprague–Dawley rats. RPMAC are negative for bacteria, yeast, fungi, and mycoplasma. |
Encephalitozoon cuniculi whole cell antigen suspension |
18-2002 |
Medicago |
1 ml |
EUR 438 |
Rat Bone Marrow Neutrophils (fresh cells in suspension) |
ABC-TC4089 |
AcceGen |
1 vial |
Ask for price |
|
Description: Rat bone marrow neutrophils (RBMNEUCs) are derived from the tibias and femurs of adult Sprague–Dawley rats. RBMNEUCs are immediately cryo-preserved or fresh cells in suspensionafter isolation. |
Glucose-6-Phosphate Dehydrogenase Suspension In 3 |
G02100 |
Pfaltz & Bauer |
1000UN |
EUR 320.28 |
Recombinant Protein A+G-Agarose suspension for Ig's purification |
PRAG15-AS-1 |
Alpha Diagnostics |
1 ml |
EUR 242.4 |
Recombinant Protein A+G-Agarose suspension for Ig's purification |
PRAG15-AS-5 |
Alpha Diagnostics |
5 ml |
EUR 781.2 |
MinuteTM Cell Suspension Isolation from Fresh/Frozen Tissues (50 tests) |
CS-031 |
Inventbiotech |
each |
EUR 299 |
Recombinant Protein A-Agarose, affinity matrix suspension for IP (100 rxn) |
PRTA16-AS-2 |
Alpha Diagnostics |
2 ml |
EUR 132 |
Recombinant Protein A-Agarose, affinity matrix suspension for IP (250 rxn) |
PRTA16-AS-5 |
Alpha Diagnostics |
5 ml |
EUR 219.6 |
Recombinant Protein G-Agarose, affinity matrix suspension for IP (100 rxn) |
PRTG16-AS-2 |
Alpha Diagnostics |
2 ml |
EUR 139.2 |
Recombinant Protein G-Agarose, affinity matrix suspension for IP (250 rxn) |
PRTG16-AS-5 |
Alpha Diagnostics |
5 ml |
EUR 255.6 |
Recombinant Protein A+G-Agarose, affinity matrix suspension for IP (100 rxn) |
PRAG25-AS-2 |
Alpha Diagnostics |
2 ml |
EUR 139.2 |
Recombinant Protein A+G-Agarose, affinity matrix suspension for IP (250 rxn) |
PRAG25-AS-5 |
Alpha Diagnostics |
5 ml |
EUR 242.4 |
Ethyl 2-Chloro-2-formylacetateTechnical Grade, 5% Suspension in Benzene |
E901885 |
Toronto Research Chemicals |
500mg |
EUR 1087 |
|
Description: 33142-21-1 |
Ethyl 2-Chloro-2-formylacetateTechnical Grade, 5% Suspension in Cyclohexane |
E901889 |
Toronto Research Chemicals |
5g |
EUR 800 |
|
Description: 33142-21-1 |
Recombinant purified Protein-L Agarose, affinity matrix suspension for IP (100 rxn) |
PRTL36-AS-2 |
Alpha Diagnostics |
2 ml |
EUR 343.2 |
European Cuscuta TaqProbe qPCR. 100 RXN |
TBS42009-100 |
Tribioscience |
100 RXN |
EUR 1100 |
European Cuscuta TaqProbe qPCR. 50 RXN |
TBS42009-50 |
Tribioscience |
50 RXN |
EUR 600 |
Automatic Decapper, European/German Standard Plug |
107001 |
NEST Biotechnology |
1 pcs/cs |
EUR 5018.31 |
Description: Automatic Decapper, European/German Standard Plug |
L.R. White Embedding Media (for European Orders only) |
17411H-500 |
Polysciences Europe GmbH |
500ml |
EUR 204 |
Description: 7732-18-5 |
L.R. White Embedding Media (for European Orders only) |
17411HUNC-500 |
Polysciences Europe GmbH |
500ml |
EUR 286 |
Description: 7732-18-5 |
L.R. White Embedding Media (for European Orders only) |
17411M-500 |
Polysciences Europe GmbH |
500ml |
EUR 204 |
Description: 7732-18-5 |
L.R. White Embedding Media (for European Orders only) |
17411MUNC-500 |
Polysciences Europe GmbH |
500ml |
EUR 286 |
Description: 7732-18-5 |
L.R. White Embedding Media (for European Orders only) |
17411S-500 |
Polysciences Europe GmbH |
500ml |
EUR 204 |
Description: 7732-18-5 |
L.R. White Embedding Media (for European Orders only) |
17411SUNC-500 |
Polysciences Europe GmbH |
500ml |
EUR 286 |
Description: 7732-18-5 |
Immortalized European Sea Bass Brain Cells (DLB-1) |
T0730 |
ABM |
1x10^6 cells / 1.0 ml |
EUR 3950 |
OPCA04490-100UG - THI2.1 Recombinant Protein (European mistletoe) |
OPCA04490-100UG |
Aviva Systems Biology |
100ug |
EUR 668 |
|
OPCA04490-20UG - THI2.1 Recombinant Protein (European mistletoe) |
OPCA04490-20UG |
Aviva Systems Biology |
20ug |
EUR 449 |
|
MyFuge™12 Mini Centrifuge 100-240V (European 2 prong plug) |
C1012-E |
Benchmark Scientific |
1 PC |
EUR 457.47 |
Incu-Mixer MP2™ Heated Plate Vortexer 115-240V European plug) |
H6002-E |
Benchmark Scientific |
1 PC |
EUR 2032.55 |
OPCA04190-1MG - Tropomyosin Recombinant Protein (European house dust mite) |
OPCA04190-1MG |
Aviva Systems Biology |
1mg |
EUR 1977 |
|
OPCA04190-20UG - Tropomyosin Recombinant Protein (European house dust mite) |
OPCA04190-20UG |
Aviva Systems Biology |
20ug |
EUR 400 |
|
Vornado™ miniature vortexer, grey cup head, 100 to 240V with European Plug |
BV101-E |
Benchmark Scientific |
1 PC |
EUR 229.09 |
OPCA04190-100UG - Tropomyosin Recombinant Protein (European house dust mite) |
OPCA04190-100UG |
Aviva Systems Biology |
100ug |
EUR 586 |
|
Orbi-Shaker™Jr with rubber mat platform (9.5"x8"), 100-240V (European 2 prong plug) |
BT302-E |
Benchmark Scientific |
1 PC |
EUR 1205.74 |
TBEV (European subtype, strain Neudoerfl) Envelope protein E, His Tag (HPLC verified) |
ENE-T52H4 |
ACROBIOSYSTEMS |
500ug |
EUR 481.5 |
|
Description: TBEV (European subtype, strain Neudoerfl) Envelope protein E, His Tag (ENE-T52H4) is expressed from human 293 cells (HEK293). It contains AA Thr 118 - Lys 675 (Accession # P14336). |
BenchWaver™ 3D Rocker with flat mat, 13.5x13" platform, 100-240V (European 2 prong plug) |
B3D5000-E |
Benchmark Scientific |
1 PC |
EUR 1548.97 |
OPCA04322-100UG - Major pollen allergen Aln g 1 Recombinant Protein (European alder) |
OPCA04322-100UG |
Aviva Systems Biology |
100ug |
EUR 668 |
|
OPCA04322-20UG - Major pollen allergen Aln g 1 Recombinant Protein (European alder) |
OPCA04322-20UG |
Aviva Systems Biology |
20ug |
EUR 449 |
|
OPCA04322-500UG - Major pollen allergen Aln g 1 Recombinant Protein (European alder) |
OPCA04322-500UG |
Aviva Systems Biology |
500ug |
EUR 1534 |
|
Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial |
CSB-EP318509TEM |
Cusabio |
11863 mg |
Ask for price |
Orbi-Shaker™ MP with 4 position micro plate platform, 100-240V (European 2 prong plug) |
BT1502-E |
Benchmark Scientific |
1 PC |
EUR 1168.82 |
Vornado™ miniature vortex mixer with red cup head, 100 to 240V with European Plug Adapter |
BV101-R-E |
Benchmark Scientific |
1 PC |
EUR 229.09 |
Vornado™ miniature vortex mixer with blue cup head, 100 to 240V with European Plug Adapter |
BV101-B-E |
Benchmark Scientific |
1 PC |
EUR 229.09 |
Vornado™ miniature vortex mixer with green cup head, 100 to 240V with European Plug Adapter |
BV101-G-E |
Benchmark Scientific |
1 PC |
EUR 229.09 |
Vornado™ miniature vortex mixer with purple cup head, 100 to 240V with European Plug Adapter |
BV101-P-E |
Benchmark Scientific |
1 PC |
EUR 229.09 |
MyFuge™12 Plus Digital Mini Centrifuge with combination rotor 100-240V (European 2 prong plug) |
C2212-E |
Benchmark Scientific |
each |
EUR 649 |
Description: - COMBI-Rotor for tubes and strips- Digital control up to 7,000 rpm / 2,739 xg!- Twice the capacity of traditional mini centrifuges- Near silent operation- Timer up to 99 mins.The unique rotor design of the new MyFuge 12 Plus eliminates the need to switch rotors (or use a separate centrifuge) when changing between microtubes and PCR strips. The included, COMBI-Rotor allows for simultaneous centrifugation of up to 12 microtubes and/or 4 PCR strips.In addition, the MyFuge 12 Plus features a large digital display with adjustable speed (up to 7,000 rpm) and a digital timer. With built in rcf conversion, speed can be set/displayed in rpm or rcf.The MyFuge 12 Plus combines power with intuitive functionality making it the perfect companion in any laboratory. |
OPCA04311-1MG - Major pollen allergen Car b 1 isoform 2 Recombinant Protein (European hornbeam) |
OPCA04311-1MG |
Aviva Systems Biology |
1mg |
EUR 2368 |
|
StripSpin™12D Digital Mini Centrifuge, holds 12 position PCR strips, 100-240V (European 2 prong plug) |
C2248-E |
Benchmark Scientific |
each |
EUR 595 |
Description: - Unique rotor accepts 12-position PCR strips- Digital control up to 5,500 rpm- “Mini” sized, less than 8 inches wide- Timer up to 99 mins.The new StripSpin 12D digital mini centrifuge from Benchmark is uniquely designed for centrifugation of 12 position PCR strips. It features digital speed control up to 5,500 rpm, timer control up to 99 min., and a safety interlock to stop the centrifuge if the lid is opened during operation.With built in rcf conversion, speed can be set/displayed in rpm or rcf, the StripSpin 12D is the perfect solution for centrifugation of up to 4 x 12-position high efficiency PCR strips (or 48 x 0.2ml tubes) and includes a 2 year warranty. |
OPCA04311-100UG - Major pollen allergen Car b 1 isoform 2 Recombinant Protein (European hornbeam) |
OPCA04311-100UG |
Aviva Systems Biology |
100ug |
EUR 668 |
|
OPCA04311-20UG - Major pollen allergen Car b 1 isoform 2 Recombinant Protein (European hornbeam) |
OPCA04311-20UG |
Aviva Systems Biology |
20ug |
EUR 449 |
|
ViPrimePLUS Porcine Reproductive and Respiratory Syndrome Virus - European Genotype RT-qPCR Kit, 1 |
QV5004 |
Vivantis |
each |
Ask for price |
MyFuge™ 5D Digital MicroCentrifuge with combination rotor, 4 x 5ml & 4 x 1.5/2.0ml, 100-240V (European 2 prong plug) |
C2205-E |
Benchmark Scientific |
each |
EUR 595 |
Description: Includes rotor for all common centrifuge tubes up to 5ml'- Digital control up to 5,500 rpm / 1,690 xg- Conserves valuable bench space- Includes adapters for common blood tubes (12 x 75 mm)- Timer up to 99 mins.The myFuge™ 5D digital mini centrifuge includes a four position rotor that accepts a variety of 5ml tubes (including 5ml snap-cap and screw-cap centrifuge tubes, as well as 5ml blood collection tubes). In addition, the rotor has four positions for positions for standard microtubes (1.5/2.0ml) and offers optional adapters for 2ml cryotubes, 0.2ml PCR tubes, and 0.5ml microtubes, making it one of the most versatile and compact centrifuges in its class.The myFuge 5D offers digital speed control (up to 5,500 rpm). Timer is also controlled (up to 99 min.) with a safety interlock to stop the centrifuge if the lid is opened during operation. With built in rcf conversion, speed can be set/displayed in rpm or rcf. The myFuge 5D also comes with a 2-year warranty. |
Sterile Pharmacol |
PW1148F-1X100NO |
EWC Diagnostics |
1 unit |
EUR 23.02 |
Description: Sterile Pharmacol |
Prime Juice DNA Staining Reagent |
LD011-1000 |
Bio-Helix |
1 ml |
EUR 10 |
PEROXIDE BLOCKING REAGENT Reagent |
GWB-Q00308 |
GenWay Biotech |
50 ml |
Ask for price |
TruStrip WBV Tubulin protein quantitation & Western Blot Validation Kit (contains actin strips, primary antibodies and Western reagents 100 strips or 10 miniblot) |
WBTUB100-K |
Alpha Diagnostics |
1 Kit |
EUR 634.8 |
Good predictions are solely of worth when delivered successfully to those that can use them. The brand new pKa prediction mannequin has been built-in into Pipeline Pilot and the PharmacophorInformatics (PIx) platform utilized by scientists at Bayer Pharma. Completely different output codecs permit custom-made software by medicinal chemists, bodily chemists, and computational chemists.