Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors.

Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors.

Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. As a result of it’s extensively utilized by proliferating cells, its inhibition in autoimmune and inflammatory illnesses, cancers, and a number of sclerosis is of considerable scientific significance. On this examine, we had two goals. The primary was to develop an hDHODH pharma-similarity index strategy...